Association of rs7903146 TCF7L2 (C/T) Gene Polymorphism and Type 2 Diabetes Mellitus in Pakistani Population
Mahmood Hassan Dalhat *
Department of Biochemistry, Usmanu Danfodiyo University Sokoto, Nigeria and Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
Haris Ja’afar Bello
Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
Bashiru Ibrahim
Department of Biochemistry, Sokoto State University, Nigeria
Abdullahi Muhammad Labbo
Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan and Department of Biochemistry, Sokoto State University, Nigeria
*Author to whom correspondence should be addressed.
Abstract
Among various genetic determinants of type 2 DM (T2DM), TCF7L2 (transcription factor 7 like 2) polymorphisms are among the few verified genetic variants with large effects on the risk of T2DM in different populations. In the current study, the single nucleotide polymorphism (SNP) rs7903146 (c.382-41435C>T) was screened in 322 T2DM cases and 226 controls by genotyping using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). The TCF7L2 SNP was found to be associated with T2DM; (odd ratio [OR] = 2.72; 95% confidence interval [CI] 2.00-3.71, P = 6.65×10-12). Therefore, we report the role of TCF7L2 variant in individuals with T2DM in Pakistani population.
Keywords: Type 2 diabetes, genetic association, transcription factor 7 like 2, Pakistan