Phytochemical Screening and Potential Antibacterial, Antifungi and Antioxidative Activities of the Leaves Extracts of Piperomia pellucida (Piperaceae)

Luciane Marlyse Moungang *

Department of Animal Biology and Physiology, Faculty of Sciences, Laboratory of Hydrobiology and Environment, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.

Brigitte Ndemangou

University of Yaounde I, University Institute of Wood Technology, Mbalmayo, P.O. Box 306, Mbalmayo, Cameroon.

Roland Ndifor Ache

Higher Technical Teachers Training College, University of Bamenda, P.O. Box 39, Bamenda, Cameroon and Department of Organic Chemistry, Faculty of Sciences, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

Lazare Sidjui Sidjui

Department of Organic Chemistry, Faculty of Sciences, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

Yvan Anderson Ngandjui

Department of Organic Chemistry, Faculty of Sciences, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

Nathalie Ngueukam

Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Science, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon.

Hortense Gonsu Kamga *

Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Center University Teaching Hospital of Yaounde, Laboratory of Bacteriology, P.O. Box 1364, Yaounde, Cameroon.

Bathelemy Ngameni

Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Science, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon.

*Author to whom correspondence should be addressed.


Abstract

The hexane, ethanolic, hydroethanolic and aqueous leaves extracts of Piperomia pellucida were evaluated in vitro for their antimicrobial activity against five gram negative bacilli (Klebsiella pneumoniae CHUY, Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853, Salmonella typhi CHUY and Salmonella enterica CHUY), two cocci gram positive (Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 5199) and two fungi (Candida albicans CHUY and Candida albicans 20231) using microdilution techniques. The extracts were also assayed for their antioxidant properties by DPPH and FRAP methods with Vitamin C as reference. The results demonstrated that, the hexane extract exhibited strong antibacterial potency with MIC value of 0.625 mg/mL and MBC of 1.25 mg/mL on Salmonella typhi CHUY. Also, it showed good activities on P. aeruginosa ATCC 27853 and S. enterica CHUY; and weak activity against E. coli ATCC 35218 and S. aureus ATCC 25923. The aqueous extract displayed good activities against S. aureus ATCC 25923, P. aeruginosa ATCC 27853, E. coli ATCC 35218, S. typhi CHUY, S enterica CHUY ; weak potency toward E. coli ATCC 35218 and was inactive on the tested fungi strains. The ethanolic and hydroethanolic extract displayed weak activities on E. coli ATCC 35218, S. enterica CHUY and S. typhi CHUY.

The strongest antioxidative activities of efficient concentrations were exhibited by the ethanolic (10.681 ± 0.530µg/mL) and the hydroethanolic extracts (16.339 ± 0.043µg/mL).

Keywords: Piperaceae, Piperomia pellucida, antibacterial, antifungi, antioxidative


How to Cite

Moungang, L. M., Ndemangou, B., Ache, R. N., Sidjui, L. S., Ngandjui, Y. A., Ngueukam, N., Kamga, H. G., & Ngameni, B. (2023). Phytochemical Screening and Potential Antibacterial, Antifungi and Antioxidative Activities of the Leaves Extracts of Piperomia pellucida (Piperaceae). Journal of Applied Life Sciences International, 26(5), 35–46. https://doi.org/10.9734/jalsi/2023/v26i5617

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