Evaluation of Empirical Functions and Fate of Isomaltose
Toluwase Hezekiah Fatoki *
Department of Biochemistry, Federal University of Technology, PMB 704, Akure, Ondo State, Nigeria
David Morakinyo Sanni
Department of Biochemistry, Federal University of Technology, PMB 704, Akure, Ondo State, Nigeria
Daniel Uwaremhevho Momodu
Department of Industrial Chemistry, Federal University Oye, PMB 373, Oye, Ekiti State, Nigeria
Harriet Unuagbon Ugboko
Department of Biological Sciences, Covenant University, PMB 1023, Ota, Ogun State, Nigeria
Catherine Joke Adeseko
Department of Biochemistry, Federal University of Technology, PMB 704, Akure, Ondo State, Nigeria
Bolanle Christianah Faleye
Department of Chemical Science, Joseph Ayo Babalola University, Ikeji-Arakeji, PMB 5006, Ilesa, Osun State, Nigeria
*Author to whom correspondence should be addressed.
Abstract
Aim: To validate the empirical functions of isomaltose and proposed its fates in metabolism using computational analysis.
Place and Duration of Study: This work was carried out at the Department of Biochemistry at the Federal University of Technology Akure Nigeria in 2017.
Methodology: We make use of text mining of experimental articles on isomaltose, predicted the potential targets using Swisstargetprediction server, and the Swisssimilarity server was used for drug similarity analysis.
Results: Isomaltose exhibits antimicrobial activity, biodegradability, non-toxic, and find its use in food, biochemistry and pharmaceutical industries as a prebiotic molecule, precursor metabolite and potent medicine respectively. Isomaltose possibly has a lower glycemic index, with the fate that implicated the production of diglucosamine, by the help of specific aminotransferase, and that there is a possibility of biosynthesis of secondary metabolites through isomaltose pathway.
Conclusion: This study provides the future areas of research and application of isomaltose.
Keywords: Isomaltose, diglucosamine, novel pathway, in silico, functions, fate