Journal of Applied Life Sciences International <p style="text-align: justify;"><strong>Journal of Applied Life Sciences International (ISSN:&nbsp;2394-1103)</strong> aims to publish high quality papers (<a href="/index.php/JALSI/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of ‘applied life sciences’. By not excluding papers on the basis of novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> en-US (Journal of Applied Life Sciences International) (Journal of Applied Life Sciences International) Sat, 06 Feb 2021 12:29:57 +0000 OJS 60 Acaricidal Activity of Commiphora merkeri Bark Exudate against Two Species of Rhipicephalus Koch (Acari; Ixodidae) by Larval and Adult Immersion Test <p>Ticks pose a threat in the infestation of both wild and domestic animals, thereby causing an increase in chances for transmission of diseases. Despite of the wide use of <em>Commiphora</em> species in tick control, no acaricidal activity of <em>Commiphora merkeri</em>. Engl.&nbsp;Exudate have been scientifically assessed. The acaricidal activity of the exudate extract and its Petroleum ether (PE), Dichloromethane (DCM) and Ethyl acetate (ETOAC) fractions were carried out by using the larval immersion test (LIT) and adult immersion test (AIT), against <em>Rhipicephalus </em><em>appendiculatus </em>and <em>Rhipicephalus averts</em>. The crude extracts of <em>C. merkeri </em>showed 80% and 70% mortality on the LIT bioassay at concentration of 1.0 mg/mL for <em>R. averts</em> and <em>R. appendiculatus, </em>respectively. There was no statistical difference (<em>p</em>≥0.05) in activity of petroleum ether and dichloromethane fractions exhibiting 100% mortality at concentration of 1.0 mg/mL for <em>R. appendiculatus </em>and <em>R. averts, </em>also at 0.8 mg/mL to <em>R. averts</em> species. <em>R. averts </em>was more susceptible that<em> R. appendiculatus </em>showing stable incremental mortality in all concentration levels. In the AIT, no statistical significant difference (<em>p</em>≥0.05) in reduction was observed for crude extract of <em>C. merkeri</em> and petroleum ether fractions by having no surviving <em>R. averts</em> above 0.025 mg/mL after 24 and 72 h. The same trend was observed for <em>R. appendiculatus</em> within 24 h of exposure. However, at lower concentrations the residual effect of treatments on the ticks continued to elicit the effect over time having few or no immediate effect of death after exposure, This was vivid for <em>R. averts</em> within 24 and after 72 h. Follow up of survived engorged adults indicated that, the ticks could lay eggs but the eggs were not viable for hatching. This justifies its uses as an alternative agent in an integrated approach in reducing tick infestation among Pastoralist.</p> Ester Innocent, Ismail Almas Athman, Suzana Augustino ##submission.copyrightStatement## Sun, 10 Jan 2021 00:00:00 +0000 In vivo Activity of Dust Inhalation at Ratcon Quarry, Sokuro Village, Oluyole, Ibadan Oyo State <p>A total of twenty (20) experimental adult male rats, aged 60 days (7 to 8 weeks) with average body weight between 150-200 gm were grouped, restrained inside laboratory approved plastic holders and exposed to dust inhalation at the quarry site with exposure time of 7, 14 and 21 days to reflect short-term effects while 42days represent long-term effects of dust inhalation on human beings. Each specimen was collected and sacrificed at their grouped survival periods and subjected to laboratory analysis that include Hematology and Histopathology of the lungs. The Hematologyresults of the 7 and 14days specimens revealed no remarkable changes in the Erythrogram (PCV, HB and RBC), the Leucogram (WBC) and the Platelets but however, the results of the 21 and 42 days specimen revealed leukocytosis (increase in WBC), lymphocytosis (increase Lym) and neutrophilia (increase neutrophils) (p&lt;0.05). The Histopathology results of the first specimen (7 days exposure) showed no observable lesion, the second specimen(14 days) showed capillary congestion and mild interstitial pneumonia, while the third (21 days) and fourth (42 days) samples showed the rats graduating from mild to moderate interstitial pneumonia and oedema. The risk of these diseases depends on the amount of organic or inorganic dusts inhaled and deposited in the alveolar region, the air concentration of respirable dust as well as the exposure time and breathing pattern.</p> Adeniyi Abayomi Olusegun ##submission.copyrightStatement## Wed, 17 Feb 2021 00:00:00 +0000 Changes in Antioxidant Markers and Histopathology of Wistar Rats Fed with Edible Clay (Nzu) <p>The changes in the antioxidant markers and histopathology in both adult male and female wistar rats fed with Calabash Chalk (nzu) was investigated. Twenty (20) wistar rats weighing between (120-150 g) were used for this study. They were randomly divided into four (4) Groups containing five (5) animals each (n=5) A-D. Groups (B-D) were fed with 1.0%, 2.0% and 8.0% of clay. Group A, not fed with clay served as control. After 21 days of continuous feeding, the animals were sacrificed and their liver organs excised for the following antioxidant markers (Catalase CAT, Reduced Glutathione GSH, Superoxide dismutase, SOD) and histopathology. The results showed significant (p&lt; 0.05) increase in catalase activity in rats fed with 1.0% and 8.0% clay compared to control (0 clay) and group fed with 2.0%. However, no significant (p&gt;0.05) difference was obtained for the group fed with 2.0% when compared to control.&nbsp; The results obtained for GSH and SOD also showed no significant (p&gt;0.05) difference in the fed groups when compared to control. Histopathological changes indicated mild periportal and intraparenchymal inflammation in group fed with 8.0%. From the study it can be deduced that clay consumption has the potential to elicit the activities of antioxidant markers and subsequent depletion providing weak defenses against reactive oxygen species (ROS) and liver damage in the rats.</p> A. Dokubo, A. E. Okwudike, K. T. Nwauche ##submission.copyrightStatement## Tue, 23 Feb 2021 00:00:00 +0000