Association between Non-secretion of ABH Antigens and Sickle Cell Anaemia

Main Article Content

C. Igbeneghu
J. M. Olisekodiaka
O. A. Fawole
A. O. Ayoola


Aim: To determine whether non-secretion of ABH blood group antigens was associated with Sickle Cell Anaemia.

Materials and Methods: Haemaglutination inhibition test was carried out on saliva samples from 300 individuals; 100 of whom had haemoglobin (Hb) genotype AA, 100 HbAS, 50 HbAC and 50 HbSS. ABO blood grouping was carried out by standard methods and Haemoglobin genotype test was performed by cellulose acetate electrophoresis technique.

Results: Eighteen percent (18%) of HbAA, 23% of HbAS, 18% of HbAC and 42% of HbSS individuals were non-secretors of ABH antigens (p = 0.007). Non-secretion of ABH substances was more associated with HbSS persons than HbAA (p = 0.002), HbAS (p = 0.016) and HbAC (p = 0.009) individuals.

Conclusion: Non-secretion of ABH blood group substances is associated with Sickle Cell Anaemia.

Haemoglobin genotype, ABO blood group, sickle cell anaemia, ABH antigens, Secretor status.

Article Details

How to Cite
Igbeneghu, C., Olisekodiaka, J. M., Fawole, O. A., & Ayoola, A. O. (2019). Association between Non-secretion of ABH Antigens and Sickle Cell Anaemia. Journal of Applied Life Sciences International, 22(1), 1-6.
Original Research Article


Igbeneghu C, Olisekodiaka MJ, Akinola FFS, Odaibo AB. Impact of haemoglobin variants AS and AC on Asymptomatic falciparum malaria among adults in Iwo, Southwestern Nigeria. SJAMS. 2015a; 3(1A):17-20.

Emechebe GO, Onyire NB, Orji ML, Achigbu KI. Sickle cell disease in Nigeria - A review. IOSR-JDMS. 2017;16(1):87-94.

Mulumba LL, Wilson L. Sickle cell disease among children in Africa: An integrative literature review and global recommendations. Intern J Afr Nursing Sci. 2015;3:56-64.

Azar S, Wong TE. Sickle cell disease: A brief update. Med Clin North Am. 2017;101(2):375-393.

Macharia AW, Mochamah G, Uyoga S, Ndila CM, Nyutu G, Makale J, Tendwa M, Nyatichi E, Ojal J, Shebe M, Awuondo KO, Mturi N, Peshu N, Tsofa B, Scott JAG, Maitland K, Williams TN. The clinical epidemiology of sickle cell anaemia in Africa. Am J Haematol. 2018;93(3):363-370.

Aygun B, Odame I. A global perspective on sickle cell disease. Pediatr Bld Cancer. 2012;59(2):386-390.

Jaff MS. Higher frequency of secretor phenotype in O blood group-its benefits in prevention and /or treatment of some diseases. Intern J Nanomed. 2010;5:901-905.

Shinebaum R, Blackwell CC, Forster PJ, Hurst NP, Weir DM, Nuki G. Non-secretion of ABO blood group antigens as host susceptibility factor in the spondyloarthropathies. BMJ (Clin Res Ed). 1987;294(6566):208-210.

Shinebaum R. ABO blood group and secretor status in the spondyloarthropathies. FEMS Microbiol Immunol. 1989;1(6-7):389-395.

Orstavik KH, Kornstad L, Reisner H, Berg K. Possible effect of secretor locus on plasma concentration of factor VIII and von Willebrand factor. Blood. 1989;73(4):990-993.

Orstavik KH. Genetics of plasma concentration of von Willebrand factor. Folia Haematol Int Mag Klin Morphol Blutforsch. 1990;117(4):527-531.

Al-Agidi SK, Shukri SM. Association between immunoglobulin levels and known genetic markers in an Iraqi population. Ann Hum Biol. 1982;9(6):565-569.

Hein HO, Sorensen H, Suadicani P, Gyntelberg F. The Lewis blood group - a new genetic marker of ischaemic heart disease. J Intern Med. 1992;232(6):481-487.

Ellison RC, Zhang Y, Myers RH, Swanson JL, Higgins M, Eckfeldt J. Lewis blood group phenotype as an independent risk factor for coronary heart disease (the NHLBI Family Heart Study). Am J Cardiol. 1999;83(3):345-348.

Robinson WM, Salzano FM, Achutti AC, Franco MH. Blood groups, salivary secretion and other immunologic variables in rheumatic fever and rheumatic heart disease. Acta Anthropogenet. 1984;8(3-4): 217-221.

Jhingham B, Mehra NK, Reddy KS, Taema V, Valdya MC, Bhatia ML. HLA, Blood groups and secretor status in patients with established rheumatic fever and rheumatic heart disease. Tissue Ag. 1986;3:172-178.

Dickey W, Collins JSA, Watson RGP, Sloan JM, Porter KG. Secretor status and Helicobacter pylori infection are independent risk factors for gastroduodenal disease. Gut. 1994;34(3): 351-353.

Olorunshola KV, Audu I. ABO (H) secretor status of sickle cell disease patients in Zaria, Kaduna State, Nigeria. Niger J Physiol Sci. 2013;28:29-34.

Igbeneghu C, Odaibo GN, Olaleye DO, Odaibo AB. Malaria infection and ABO blood grouping in Iwo community, Southwestern Nigeria. Res J Med Sci. 2012;6(5):247-250.

Igbeneghu C, Olisekodiaka JM, Alabi T, Onuegbu JA, Oseni BA, Odaibo A. ABH secretors status in Osogbo, Southwestern Nigeria. Indian J Fund Appl Life Sci. 2015b;5(3):42-47.

Emeribe AO, Igweagu CA, Ossim EE. ABH secretor status in saliva of Calabar Municipal residents. East Afr Med J. 1992;69(1):27-30.

Igbeneghu C, Olisekodiaka MJ, Okanlawon BM, Onuegbu JA, Odaibo AB. Non-secretors of ABH antigens are susceptible to falciparum malaria. SJAMS. 2015c;3(5A):1838-1841.

Falusi AG, Ademowo CA, Latunji CA, Okeke AC, Olatunji PO, Onyekwere TO, Jimmy EO, Raji Y. Distribution of ABO and Rh genes in Nigeria. Afr J Med Med Sci. 2000;29:23-26.

Bakare AA, Azeez MA, Agbolade JO. Gene frequencies of ABO and rhesus blood groups and haemoglobin variants in Ogbomoso, Southwest Nigeria. Afr J Biotech. 2006;5(3):224-229.

Kapoor S, Little JA, Pecker LH. Advances in the treatment of sickle cell disease. Mayo Clin Proc. 2018;93(12):1810-1824.

Raza MW, Backwell CC, James VS, Ogilvie MM, Weir DM, Molyneaux P, et al. Association between secretor status and respiratory viral illness. BMJ. 1991;303: 815-818.